Jayaraman Research Group

Research Areas

1. Aryl Hydrocarbon Receptor (AhR) Signaling

  • Han, H., Davidson, L. A., Fan, Y., Landrock, K. K., Jayaraman, A., Safe, S. H., & Chapkin, R. S. (2022). Loss of aryl hydrocarbon receptor suppresses the response of colonic epithelial cells to IL22 signaling by upregulating SOCS3. American Journal of Physiology – Gastrointestinal and Liver Physiology, 322(1), G93–G106.

  • Yang, Y., Osorio, D., Davidson, L. A., Han, H., Mullens, D. A., Jayaraman, A., Ivanov, I. V., Cai, J. J., & Chapkin, R. S. (2022). Single-cell RNA Sequencing Reveals How the Aryl Hydrocarbon Receptor Shapes Cellular Differentiation Potency in the Mouse Colon. Cancer Prevention Research, 15(1), 17–28.

  • Chapkin, R. S., Davidson, L. A., Park, H., Jin, U., Fan, Y., Cheng, Y., Jayaraman, A., & Safe, S. (2021). Role of the Aryl Hydrocarbon Receptor (AhR) in Mediating the Effects of Coffee in the Colon. Molecular Nutrition and Food Research, 65(20), e2100539.

  • Han, H., Safe, S., Jayaraman, A., & Chapkin, R. S. (2021). Diet-Host-Microbiota Interactions Shape Aryl Hydrocarbon Receptor Ligand Production to Modulate Intestinal Homeostasis. Annual Review of Nutrition, 41(1), 455–478.

  • Han, H., Davidson, L. A., Hensel, M., Yoon, G., Landrock, K., Allred, C., Jayaraman, A., Safe, S. H., & Chapkin, R. S. (2021). Loss of Aryl Hydrocarbon Receptor Promotes Colon Tumorigenesis in $Apc^{S580/+}; Kras^{G12D/+}$ Mice. Molecular Cancer Research, 19(5), 771–783.

  • Park, H., Jin, U., Karki, K., Allred, C., Davidson, L. A., Chapkin, R. S., Orr, A. A., Nowshad, F., Jayaraman, A., Tamamis, P., & Safe, S. (2021). Hydroxylated Chalcones as Aryl Hydrocarbon Receptor Agonists: Structure-Activity Effects. Toxicological Sciences, 180(1), 148–159.

2. Diet, Gut Microbiota, & Microbial Metabolites

  • Glan, E. E. [Gülşan, E. E.], Nowshad, F., Leigh, M. D., Crott, J. W., Park, H., Martin, G., Safe, S., Chapkin, R. S., Jayaraman, A., & Lee, K. (2025). A Chalcone Synthase-like Bacterial Protein Catalyzes Heterocyclic C-Ring Cleavage of Naringenin to Alter Bioactivity Against Nuclear Receptors in Colonic Epithelial Cells. Metabolites, 15(3), 146.

  • Ding, Y., Yanagi, K., Yang, F., Callaway, E., Cheng, C., Hensel, M. E., Menon, R., Alaniz, R. C., Lee, K., & Jayaraman, A. (2024). Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice. eLife, 12, rp87458.

  • Safe, S., Jayaraman, A., Chapkin, R. S., Howard, M., Mohankumar, K., & Shrestha, R. (2021). Flavonoids: structure-function and mechanisms of action and opportunities for drug development. Toxicological Research, 37(2), 147–162.

  • Wu, C., Muthyala, S., Klemashevich, C., Ufondu, A. U., Menon, R., Chen, Z., Jayaraman, A., & Sun, Y. (2021). Age-dependent remodeling of gut microbiome and host serum metabolome in mice. Aging, 13(5), 6330–6345.

  • Chen, Y., Li, J., Menon, R., Jayaraman, A., Lee, K., Huang, Y., Dashwood, W. M., Zhang, K., Sun, D., & Dashwood, R. H. (2021). Dietary spinach reshapes the gut microbiome in an Apc-mutant genetic background: mechanistic insights from integrated multi-omics. Gut Microbes, 13(1), 1972756.

3. Microfluidic Models

  • Penarete-Acosta, D., Mittal, M., Chakraborty, S., Han, A., & Jayaraman, A. (2025). Interplay between dietary fiber, macrophages and colonocytes in a microfluidic model of host-microbiota interactions in colorectal cancer. Lab on a Chip, 25(21), 5482–5496.

  • Penarete-Acosta, D., Stading, R., Emerson, L., Horn, M., Chakraborty, S., Han, A., & Jayaraman, A. (2024). A microfluidic co-culture model for investigating colonocytes-microbiota interactions in colorectal cancer. Lab on a Chip, 24(15), 3690–3703.

  • Goldsberry, R., Martin, U., Bond, B., Callaway, E., Castaneda, H., & Jayaraman, A. (2024). Applicability of microcapillary electrochemical droplet cell for monitoring microbiologically induced corrosion. Electrochemistry Communications, 168, 107822.

  • Lei, M., Jayaraman, A., Van Deventer, J. A., & Lee, K. (2021). Engineering Selectively Targeting Antimicrobial Peptides. Annual Review of Biomedical Engineering, 23(1), 339–357.

  • Eshghjoo, S., Kim, D. M., Jayaraman, A., Sun, Y., & Alaniz, R. C. (2021). A Comprehensive High-Efficiency Protocol for Isolation, Culture, Polarization, and Glycolytic Characterization of Bone Marrow-Derived Macrophages. Journal of Visualized Experiments, (168), e62184.

4. Systemic Metabolomics

  • Baranwal, G., Pilla, R., Goodlett, B. L., Coleman, A. K., Arenaz, C. M., Jayaraman, A., Rutkowski, J. M., Alaniz, R. C., & Mitchell, B. M. (2021). Common Metabolites in Two Different Hypertensive Mouse Models: A Serum and Urine Metabolome Study. Biomolecules, 11(9), 1387.

  • Baranwal, G., Pilla, R., Goodlett, B., Jayaraman, A., Rutkowski, J. M., Alaniz, R., & Mitchell, B. M. (2021). Metabolomic Study To Identify Common Metabolites In Two Different Mouse Models Of Hypertension. Hypertension, 78(Suppl_1), amp42.

  • Eshghjoo, S., Jayaraman, A., Sun, Y., & Alaniz, R. C. (2021). Microbiota-Mediated Immune Regulation in Atherosclerosis. Molecules, 26(1), 179.